Trigen Pharma | Product

TriCardin

TriCardin is the only medicine in the world that treats the entire cardiovascular system and is used as the first line of treatment.

Info on TriCardin

TriCardin is the only medicine in the world that treats the entire cardiovascular system and is used as the first line of treatment.

How TriCardin works

By producing anti-inflammatory beneficial effects on entire Cardiovascular System as follows:

Preservation and improvement in heart function.
Prevention and protection of vascular endothelium.
Enhancing blood flow.
Reduction in Cholesterol, Low Density Lipoprotein and Triglycerides with improved High Density Lipoprotein.

How it’s different from others

TriCardin has emerged as the world’s best medicine for Ischemic Heart Disease and Microangiopathies.

100% imported.
Improves Microcirculation at all levels.
World’s only medicine to treat entire cardiovascular system.
Potent activity as anti-atherosclerosis, anti-arteriosclerosis, anti-platelet, anti-coagulant, anti-thrombotic, anti-hyperlipidemic and anti-oxidant.
Most potent “First Line of Treatment” for angina patients – significantly reduces angina episodes within weeks.
Improves ETT & ECG significantly within weeks (based on the results of numerous clinical trials conducted Internationally and in Pakistan).
Prevent relapse and post procedure complications of coronary angioplasty and CABG.
TriCardin significantly controls high blood pressure by eliminating vascular resistance caused by impaired microcirculation.
Improves general condition of the patient within days.
Improves angina functional class and quality of life.
World’s only authentic and potent medicine used for successful prevention and treatment of vascular complications of diabetes, end organ damage secondary to hypertension, stroke, metabolic syndrome, peripheral vascular disease and other microangiopathies.
Manufactured on 4th Generation Hi-Tech “Dripping Pills Technology Plant” which is the only of its kind in the world (It ensures rapid absorption and quick onset of action). This innovative technology is protected by 280 patients worldwide.
Backed by “Multi-Finger Print Technology” which ensures 99.99% purity and exact composition of the drug.
Duly approved by State Food and Drug Administration (SFDA), Ministry of Health (China).
Due to it's innovative production technology, out-standing efficacy and very high safety profile TriCardin-Danshen Di Wan, has been declared as the "State Protected Medicine" by the Government of People's Republic of China.
TriCardin - Cardio Tonic Pills is registered by Ministry of Health in 34 Countries and being successfully used and appreciated by the medical profession.
Very high safety profile. No Side effects. No drug interaction.

Benefits of TriCardin

Improves Microcirculation at all levels.
Significantly controls high blood pressure by eliminating vascular resistance caused by impaired microcirculation.
Clinical benefits include anti-anginal, anti-atherosclerosis, anti arteriosclerosis, anti-platelet, anti-coagulant, anti-thrombotic and myocardial protective effects for synergistic improvements in cardiovascular diseases.

Side Effects

TriCardin being a natural product is extremely safe. 700 times the adult therapeutic dose failed to kill any experimental animal. TriCardin, however, should not be used in patients on Heparin or Warfarin therapy without consulting your Doctor.

Dosing Information:

Emergency Use: In case of angina attack, for quick relief, open 1 or 2 TriCardin Caps. and put its contents under the tongue (sublingually) if required – same may be repeated after every 5-10 minutes
Usual Dose: 2 capsules, 2-3 times daily
Maintenance Dose: 1 capsule, 2-3 times daily

Contraindications:

Pregnant & Lactating women
Patients on Warfarin/Heparin

Note:

Clinical Trials have shown that patients can discontinue taking nitrates and anti-platelets when using TriCardin

What makes it unique

Significantly reduce angina episodes and improves Functional Class within weeks
Significant improvement in ECG & ETT
Significant improvement in Ejection Fraction (EF)
Significantly improves general condition/quality of life of the patient
Prevent post procedural complications of coronary angioplasty and CABG

Where it’s comes from

TriCardin is researched and produced by Tasly Group, which is China's largest pharmaceutical group. TRICARDIN is a unique combination formula whose potent activity and quick results is due to the use of Multi-Finger Print Technology to guarantee quality and internationally patented Dripping Pills Technology (the only of its kind in the world!). This combination of high technology and high quality makes TriCardin the market leader and incomparable with any other Danshenform preparation in the market.

The Dripping Pills Advantage

TriCardin is the only medicine in the world manufactured by State of the Art Dripping Pills technology which ensures extremely rapid absorption and quick onset of action. These combined effects produce quick improvement in patient’s symptoms.

TriCardin Mode of Action As Mentioned in International Journals

TriCardin works on blood vessels:

TriCardin inhibits endothelium derived vasoconstrictor endothelin-1. (Journal of Thoracic & Cardiovascular Surgery 2003;126:1404-1410)
TriCardin improves endothelium derived prostacyclin (PGI2) and inhibits thromboxane A2 and B2, hence reduces myocardial damage and attenuates vasoactive mediator imbalance. (Journal of Clinical Pharmacology 2005;45:1345-1359)(Journal of Thoracic & Cardiovascular Surgery, 2003;126;1404-1410)
TriCardin inhibits the activation of nuclear transcription factor NF-kB by blocking its translocation from cytoplasm to nuclei. (Journal of Cardiovascular Pharmacology Vol 45, No. 5 .May 2005)
TriCardin stimulates GSH synthesis (an intracellular antioxidant) which inhibits NF-kB activation and resultant adhesion molecule expression. (Journal of Cardiovascular Pharmacology Vol 45, No. 5 May 2005)

TriCardin works on blood:

Inhibits mast cell degranulation. (Pharmacology & Therapeutics Vol. 117 issue 2 Feb. 2008 P 280-295)
Inhibits cytokines (IL-1, IL-6, TNFα) released from endothelial cells, mast cells and leukocytes. (Pharmacology & Therapeutics Vol. 117 issue 2 Feb. 2008 P 280-295)
TriCardin decreases adhesion of HI 60 to TNFα endothelial cells. (Journal of Cardiovascular Pharmacology Vol 45, No. 5 May 2005)
TriCardin effectively reduces the expression of VCAM-1 and ICAM-1 on vascular endothelium. (Journal of Cardiovascular Pharmacology Vol 45, No. 5 May 2005)
TriCardin significantly decreases P-selectin, G llb/llla expression and intracellular calcium in both unactivated and ADP activated platelets. (Blood Coagulation & Fibrinolysis 17:259-264, 2006. Lippincott Williams & Wilkins)
TriCardin dissolves preformed microthrombi, interferes with extrinsic blood coagulation and exhibit antithrombin III like activity. (Annals of Pharmacotherapy 2001 April, Volume 35, No.4, pp.501-504)

TriCardin works on heart:

TriCardin stimulates nitric oxide production of endothelial cells by increasing endothelial nitric oxide synthase (eNOS) expression level. (Pharmacology & Therapeutics Vol. 117 Issue 2 Feb. 2008 P 280-295)
TriCardin scavenge oxygen free radicals and inhibits myocardial cell apoptosis. (Journal of Clinical Pharmacology 2005;45:1345-1359)
Inhibits Ca++ aggregation in cardiac cells and prevents calcium overload. (Journal of Clinical Pharmacology 2005;45:1345-1359)
TriCardin inhibits homocysteine and protects the myocardial cells against homocystenemia. (Journal of Clinical Pharmacology 2005;45:1345-1359)
TriCardin inhibits DNA synthesis of non cardiomyocytes and also inhibits stress activated protein (SAP) kinase activity, leading to protection from ischemia reperfusion injury. (Journal of Clinical Pharmacology 2005;45:1345-1359)

TriCardin works on lipid profile:

TriCardin inhibits LDL oxidation by inhibiting 1-diphenyl-2-picrylhydrazyl radicals leading to prevention of uptake of LDL by cultured macrophages. (Journal of American Heart Association. 1998;18;481-486)
Total cholesterol, triglycerides and LDL cholesterol levels were significantly reduced by 28.3%, 34.3% and 29.9% respectively and HDL cholesterol was significantly high by 33.2%. (Journal of Clinical Pharmacology, 2005;45:1345-1359)